Transforming growth factor beta receptor 3 (TGFBR3)-associated membranous nephropathy
نویسندگان
چکیده
منابع مشابه
Urinary transforming growth factor-beta 1 in membranous glomerulonephritis.
BACKGROUND Human idiopathic membranous glomerulonephritis (MGN) has a highly variable clinical course and factors determining its outcome are poorly known. Since transforming growth factor-beta 1 (TGF-beta 1) has an essential role in renal fibrogenesis, we studied the possibility to use urinary excretion of TGF-beta 1 in the assessment of progression of the disease in patients with MGN. METHO...
متن کاملTGFBR 3 ( transforming growth factor , beta receptor III )
TbetaRIII is an 853 amino acid transmembrane proteoglycan, which contains a short 41 amino acid cytoplasmic domain. TbetaRIII is a proteoglycan which contains glycosaminoglycan (GAG) side chain modifications (S535 and S546) composed of heparin and chondroitin sulfate. The TbetaRIII core has predicted molecular weight of 100 kDa, however fully processed TbetaRIII migrates at an apparent molecula...
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R failure is a common and serious complication of longstanding diabetes mellitus. Diabetes is now the most common cause of end-stage renal failure requiring dialysis in the United States, accounting for almost 40% of all new dialysis patients (1). Moreover, the incidence of renal failure caused by diabetes, particularly type II diabetes, is rising dramatically worldwide (2). Compounding the tra...
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Mutations in the gene for the latent transforming growth factor beta binding protein 4 (LTBP4) cause autosomal recessive cutis laxa type 1C. To understand the molecular disease mechanisms of this disease, we investigated the impact of LTBP4 loss on transforming growth factor beta (TGFβ) signaling. Despite elevated extracellular TGFβ activity, downstream signaling molecules of the TGFβ pathway, ...
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Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-β1 has been demon...
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ژورنال
عنوان ژورنال: Kidney360
سال: 2021
ISSN: 2641-7650,2641-7650
DOI: 10.34067/kid.0001492021